Príbalový leták Nebido 1000 mg 4 ml injekčný roztok

Serum levels below normal range would indicate the need for a shorter injection interval. In case of high serum levels an extension of the injection interval may be considered. Treatment with high doses of testosterone preparations commonly stops or reduces sperm production, although this returns to normal after treatment ceases.

Nebido 1000mg/4 ml side effects

• It also performs functions, e.g.  in the skin, muscles, skeleton, kidney, liver, bone marrow, and CNS.
• The patient should therefore be observed during and immediately after each injection in order to allow for early recognition of possible signs and symptoms of pulmonary oily microembolism.
• Athletes treated for testosterone replacement in primary and secondary male hypogonadism should be advised that the medicinal product contains an active substance which may produce a positive reaction in anti-doping tests.
• High-dosed or long-term administration of testosterone occasionally increases the occurrences of water retention and oedema.

Nebido should not be used by women and should not be used by pregnant or breastfeeding women. Nebido shouldnot be used to build muscle or improve the physical performance of individuals who do not need treatment with Nebido for medical reasons. Your doctor will not need to adjust your dose if you are over 65 years of age (see ” Medical examination/follow-up” ). Suspected anaphylactic reactions after Testosterone Undecanoate injection have been reported. Testosterone Undecanoate is not for use in women and must not be used in pregnant or breast-feeding women.

An increase in serum levels of testosterone above basal values may be seen one day after administration. The way that Nebido https://qualitynetfoundation.org/2024/10/14/how-steroids-help-bodybuilders-elevate-fitness/ works is that it is injected into your body, usually into a muscle within the body. When it is injected, it is stored within the body and is gradually released over a period of time. This provides an evenly distributed effect that increases the effectiveness of the injection.

what you need to know before you are given testosterone undecanoate

Your doctor may give you the second injection after 6 weeks to quickly reach the required testosterone level, depending on your symptoms and testosterone levels. In patients suffering from severe cardiac, hepatic or renal insufficiency or ischaemic heart disease, treatment with testosterone may cause severe complications characterised by oedema with or without congestive cardiac failure. In clinical studies of 104 patients treated with Nebido 1000mg/4 ml (Nebido 1000mg/4 ml (transdermal)), the most common adverse effects reported were local effects. In US clinical trials, most of the 72 patients filling out a daily questionnaire reported scrotal itching, discomfort, or irritation at some time during therapy. Of all the daily questionnaire responses, 7% reported itching, 4% discomfort, and 2% irritation.

Adverse events reported during use of a given product may occur in patients who are treated with any Nebido 1000mg/4 ml (Nebido 1000mg/4 ml (transdermal)) product. Androgens may decrease levels of thyroxin-binding globulin, resulting in decreased total T. Nebido 1000mg/4 ml enanthate is used in women to treat breast cancer that has spread to other parts of the body (metastatic) and cannot be treated with surgery. There is no data available on the use of Nebido in males under 18 years of age. After removal of the plastic cap (A) do not remove the metal ring (B) or the crimp cap ©. The contents of a vial are to be injected intramuscularly immediately after opening the vial.

It also performs functions, e.g. in the skin, muscles, skeleton, kidney, liver, bone marrow and CNS. Your doctor will give you your injections less often or end the treatment. Following the use of hormonal substances such as androgenic compounds, cases of benign (non-carcinogenic) and malignant (carcinogenic) liver tumors have been observed. There is no data available on the use of Testosterone Undecanoate in males under 18 years of age. Each ml of solution contains 250 mg testosterone undecanoate equivalent to 157.9 mg testosterone.

Fertility studies in rodents and primates have shown that treatment with testosterone can impair fertility by suppressing spermatogenesis in a dose dependent manner. The undecanoic acid is metabolised by ß -oxidation in the same way as other aliphatic carboxylic acids. Only the free fraction of testosterone is considered as biologically active. Following intravenous infusion of testosterone to elderly men, the elimination half-life of testosterone was approximately one hour and an apparent volume of distribution of about 1.0 l/kg was determined.

Following intramuscular administration of this depot formulation the release rate is characterised by a half life of 90±40 days. As a general rule, the limitations of using intramuscular injections in patients with acquired or inherited blood clotting irregularities always have to be observed. Caution should be exercised in patients predisposed to oedema, as treatment with androgens may result in increased sodium retention (see section 4.8).

This is enough to maintain sufficient testosterone levels without leading to a build-up of testosterone in the blood. Caution should be exercised in patients predisposed to oedema, e.g. in case of severe cardiac, hepatic, or renal insufficiency or ischaemic heart disease, as treatment with androgens may result in increased retention of sodium and water. In case of severe complications characterized by oedema with or without congestive heart failure treatment must be stopped immediately (see section 4.8). Your doctor will inject Testosterone Undecanoate (1 vial) very slowly into a muscle.

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